| 2020-10-27 19:00:22October 27, 2020 | Leyton Orient vs Exeter City | 19:00:227:00 pm | League 2 | Brisbane Road |
| 2020-10-31 15:00:26October 31, 2020 | Exeter City vs Carlisle United | 15:00:263:00 pm | League 2 | St James Park, Exeter |
| 2020-11-03 18:30:03November 3, 2020 | Morecambe vs Exeter City | 18:30:036:30 pm | League 2 | Christie Park, Morecambe |
| 2020-11-14 15:00:16November 14, 2020 | Bradford City vs Exeter City | 15:00:163:00 pm | League 2 | Valley Parade, Bradford |
| 2020-11-17 19:00:11November 17, 2020 | Exeter City vs West Brom U21 | 19:00:117:00 pm | EFL Trophy | St James Park, Exeter |
| 2020-11-21 15:00:29November 21, 2020 | Exeter City vs Oldham Athletic | 15:00:293:00 pm | League 2 | St James Park, Exeter |
| 2020-11-24 19:45:36November 24, 2020 | Exeter City vs Colchester United | 19:45:367:45 pm | League 2 | St James Park, Exeter |
| 2020-12-01 19:00:28December 1, 2020 | Grimsby Town vs Exeter City | 19:00:287:00 pm | League 2 | Blundell Park, Grimsby |
| 2020-12-05 15:00:06December 5, 2020 | Cheltenham Town vs Exeter City | 15:00:063:00 pm | League 2 | Whaddon Road, Cheltenham |
| 2020-12-12 15:00:30December 12, 2020 | Exeter City vs Tranmere Rovers | 15:00:303:00 pm | League 2 | St James Park, Exeter |
| 2020-12-15 18:30:30December 15, 2020 | Exeter City vs Harrogate Town | 18:30:306:30 pm | League 2 | St James Park, Exeter |
| 2020-12-19 15:00:58December 19, 2020 | Stevenage FC vs Exeter City | 15:00:583:00 pm | League 2 | Broadhall Way, Stevenage |
| 2020-12-26 13:00:51December 26, 2020 | Exeter City vs Forest Green Rovers | 13:00:511:00 pm | League 2 | St James Park, Exeter |
| 2020-12-29 15:00:47December 29, 2020 | Newport County vs Exeter City | 15:00:473:00 pm | League 2 | Rodney Parade, Newport |
| 2021-01-02 15:00:14January 2, 2021 | Barrow AFC vs Exeter City | 15:00:143:00 pm | League 2 | Holker Street |
| 2021-01-09 15:00:10January 9, 2021 | Exeter City vs Bolton Wanderers | 15:00:103:00 pm | League 2 | St James Park, Exeter |
| 2021-01-16 15:00:31January 16, 2021 | Harrogate Town vs Exeter City | 15:00:313:00 pm | League 2 | Wetherby Road |
| 2021-01-23 15:00:42January 23, 2021 | Exeter City vs Stevenage FC | 15:00:423:00 pm | League 2 | St James Park, Exeter |
| 2021-01-26 19:45:17January 26, 2021 | Exeter City vs Mansfield Town | 19:45:177:45 pm | League 2 | St James Park, Exeter |
| 2021-01-30 15:00:37January 30, 2021 | Carlisle United vs Exeter City | 15:00:373:00 pm | League 2 | Brunton Park, Carlisle |
| 2021-02-06 15:00:27February 6, 2021 | Exeter City vs Bradford City | 15:00:273:00 pm | League 2 | St James Park, Exeter |
| 2021-02-13 15:00:27February 13, 2021 | Oldham Athletic vs Exeter City | 15:00:273:00 pm | League 2 | Boundary Park, Oldham |
| 2021-02-20 15:00:51February 20, 2021 | Exeter City vs Grimsby Town | 15:00:513:00 pm | League 2 | St James Park, Exeter |
| 2021-02-23 19:45:08February 23, 2021 | Colchester United vs Exeter City | 19:45:087:45 pm | League 2 | Colchester Community Stadium |
| 2021-02-27 15:00:55February 27, 2021 | Crawley Town vs Exeter City | 15:00:553:00 pm | League 2 | Broadfield Stadium, Crawley |
| 2021-03-02 19:45:38March 2, 2021 | Exeter City vs Walsall | 19:45:387:45 pm | League 2 | St James Park, Exeter |
| 2021-03-06 15:00:25March 6, 2021 | Exeter City vs Leyton Orient | 15:00:253:00 pm | League 2 | St James Park, Exeter |
| 2021-03-09 19:45:21March 9, 2021 | Scunthorpe United vs Exeter City | 19:45:217:45 pm | League 2 | Glanford Park, Scunthorpe |
| 2021-03-13 15:00:14March 13, 2021 | Exeter City vs Cheltenham Town | 15:00:143:00 pm | League 2 | St James Park, Exeter |
| 2021-03-20 15:00:32March 20, 2021 | Tranmere Rovers vs Exeter City | 15:00:323:00 pm | League 2 | Prenton Park, Tranmere |
| 2021-03-27 15:00:46March 27, 2021 | Exeter City vs Salford City | 15:00:463:00 pm | League 2 | St James Park, Exeter |
| 2021-04-02 15:00:15April 2, 2021 | Port Vale vs Exeter City | 15:00:153:00 pm | League 2 | Vale Park, Port Vale |
| 2021-04-05 15:00:12April 5, 2021 | Exeter City vs Mansfield Town | 15:00:123:00 pm | League 2 | St James Park, Exeter |
| 2021-04-10 15:00:58April 10, 2021 | Cambridge United vs Exeter City | 15:00:583:00 pm | League 2 | Abbey Stadium, Cambridge |
| 2021-04-17 15:00:19April 17, 2021 | Exeter City vs Southend United | 15:00:193:00 pm | League 2 | St James Park, Exeter |
| 2021-04-20 19:45:40April 20, 2021 | Forest Green Rovers vs Exeter City | 19:45:407:45 pm | League 2 | New Lawn The, Nailsworth |
| 2021-04-24 15:00:58April 24, 2021 | Exeter City vs Newport County | 15:00:583:00 pm | League 2 | St James Park, Exeter |
| 2021-05-01 15:00:08May 1, 2021 | Bolton Wanderers vs Exeter City | 15:00:083:00 pm | League 2 | Burnden Way, Bolton |
| 2021-05-08 15:00:04May 8, 2021 | Exeter City vs Barrow AFC | 15:00:043:00 pm | League 2 | St James Park, Exeter |
