| 2021-01-19 18:30:31January 19, 2021 | Harrogate Town vs Exeter City | 18:30:316:30 pm | League 2 | Wetherby Road |
| 2021-01-23 13:00:42January 23, 2021 | Exeter City vs Stevenage FC | 13:00:421:00 pm | League 2 | St James Park, Exeter |
| 2021-01-26 18:00:17January 26, 2021 | Exeter City vs Morecambe | 18:00:176:00 pm | League 2 | St James Park, Exeter |
| 2021-01-30 13:00:37January 30, 2021 | Carlisle United vs Exeter City | 13:00:371:00 pm | League 2 | Brunton Park, Carlisle |
| 2021-02-02 19:00:58February 2, 2021 | Stevenage FC vs Exeter City | 19:00:587:00 pm | League 2 | Broadhall Way, Stevenage |
| 2021-02-06 15:00:27February 6, 2021 | Exeter City vs Bradford City | 15:00:273:00 pm | League 2 | St James Park, Exeter |
| 2021-02-09 19:00:14February 9, 2021 | Barrow AFC vs Exeter City | 19:00:147:00 pm | League 2 | Holker Street |
| 2021-02-13 15:00:27February 13, 2021 | Oldham Athletic vs Exeter City | 15:00:273:00 pm | League 2 | Boundary Park, Oldham |
| 2021-02-16 19:00:47February 16, 2021 | Newport County vs Exeter City | 19:00:477:00 pm | League 2 | Rodney Parade, Newport |
| 2021-02-20 15:00:51February 20, 2021 | Exeter City vs Grimsby Town | 15:00:513:00 pm | League 2 | St James Park, Exeter |
| 2021-02-23 19:45:08February 23, 2021 | Colchester United vs Exeter City | 19:45:087:45 pm | League 2 | Colchester Community Stadium |
| 2021-02-27 15:00:55February 27, 2021 | Crawley Town vs Exeter City | 15:00:553:00 pm | League 2 | Broadfield Stadium, Crawley |
| 2021-03-02 19:45:38March 2, 2021 | Exeter City vs Walsall | 19:45:387:45 pm | League 2 | St James Park, Exeter |
| 2021-03-06 15:00:25March 6, 2021 | Exeter City vs Leyton Orient | 15:00:253:00 pm | League 2 | St James Park, Exeter |
| 2021-03-09 19:45:21March 9, 2021 | Scunthorpe United vs Exeter City | 19:45:217:45 pm | League 2 | Glanford Park, Scunthorpe |
| 2021-03-13 15:00:14March 13, 2021 | Exeter City vs Cheltenham Town | 15:00:143:00 pm | League 2 | St James Park, Exeter |
| 2021-03-20 15:00:32March 20, 2021 | Tranmere Rovers vs Exeter City | 15:00:323:00 pm | League 2 | Prenton Park, Tranmere |
| 2021-03-27 15:00:46March 27, 2021 | Exeter City vs Salford City | 15:00:463:00 pm | League 2 | St James Park, Exeter |
| 2021-04-02 15:00:15April 2, 2021 | Port Vale vs Exeter City | 15:00:153:00 pm | League 2 | Vale Park, Port Vale |
| 2021-04-05 15:00:12April 5, 2021 | Exeter City vs Mansfield Town | 15:00:123:00 pm | League 2 | St James Park, Exeter |
| 2021-04-10 15:00:58April 10, 2021 | Cambridge United vs Exeter City | 15:00:583:00 pm | League 2 | Abbey Stadium, Cambridge |
| 2021-04-17 15:00:19April 17, 2021 | Exeter City vs Southend United | 15:00:193:00 pm | League 2 | St James Park, Exeter |
| 2021-04-20 19:45:40April 20, 2021 | Forest Green Rovers vs Exeter City | 19:45:407:45 pm | League 2 | New Lawn The, Nailsworth |
| 2021-04-24 15:00:58April 24, 2021 | Exeter City vs Newport County | 15:00:583:00 pm | League 2 | St James Park, Exeter |
| 2021-05-01 15:00:08May 1, 2021 | Bolton Wanderers vs Exeter City | 15:00:083:00 pm | League 2 | Burnden Way, Bolton |
| 2021-05-08 15:00:04May 8, 2021 | Exeter City vs Barrow AFC | 15:00:043:00 pm | League 2 | St James Park, Exeter |
